Positive Topline Results for AMT-130

On 24 September, uniQure announced exciting topline results for their Phase 1/2 study of AMT-130 in HD. The high dose of AMT-130 met the study’s primary endpoint by demonstrating statistically significant slowing of disease progression (as assessed by the composite Unified Huntington’s Disease Rating Scale) at 36 months compared to a propensity score-matched external control […]

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Enroll-HD periodic dataset – PDS7

The seventh release of the Enroll-HD periodic dataset, PDS7, has been fully curated and is now available. PDS7 contains data from 30,511 Enroll-HD study participants encompassing 112,992 study visits, making it one of the largest cohort datasets available to researchers. Read more here. […]

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next steps for Pridopidine

On 25 July, Prilenia shared that the application for pridopidine had been rejected for marketing authorisation in HD by the European Medicines Agency’s Committee for Medicinal Products for Human Use. The application was based on post-hoc analyses from the EHDN-endorsed, Phase 3 PROOF-HD study, suggesting that the orally administered sigma-1 receptor agonist may offer potential […]

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EHDN Newsletter – 55th edition

The EHDN newsletter (archive) aims to communicate the network’s activities and other developments of interest in the field of Huntington’s disease to the lay community, healthcare professionals and scientists. It appears three times a year (March 1, July 1, Nov 1). To receive EHDN news going forward, please subscribe to the EHDN news at the […]

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Postcard from Palm Springs 2025

Published by CHDI, ‘Postcards From…’ is a series of short videos aimed at non-scientists that conveys the major themes, scientific breakthroughs, and clinical trial updates from each year’s Huntington’s Disease Therapeutics Conference held (most usually) in Palm Springs, California. Beginning in 2006, this series of conferences is a unique forum where researchers from academia meet […]

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MDS-PAS and EHDN Joint Online Course Series: Multidisciplinary Management of Huntington’s Disease

Serie de Cursos Conjuntos en Línea MDS-PAS y EHDN: Manejo Multi- disciplinario de la Enfermedad de Huntington Course Format Start Date End Date Live Online Fri, Aug 15, 2025 Fri, Aug 22, 2025 Program Description Serie de Cursos Conjuntos en Línea MDS-PAS y EHDN: Manejo Multi- disciplinario de la Enfermedad de Huntington: Retos actuales y […]

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