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CHDI’s 18th Annual HD Therapeutics Conference – scientific presentations

CHDI’s 18th Annual HD Therapeutics Conference took place April 24 – 27, 2023, in Dubrovnik, Croatia, to allow more Europe-based colleagues to attend. This unique conference series focuses on drug discovery and development for Huntington’s disease, drawing participants from the biotech and pharmaceutical sectors as well as academia. The conference is intended as a forum […]

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UniQure Biopharma B.V. HD GeneTRX2 study endorsed* by EHDN

Study aims and goal: A Phase Ib/II Study to Explore Safety, Tolerability, and Efficacy Signals of Multiple Ascending Doses of Striatally-Administered rAAV5-miHTT Total Huntingtin Gene (HTT) Lowering Therapy (AMT 130) in Early Manifest Huntington’s Disease. No. of study participants and sites: This phase Ib/II b study aims to recruit 15 participants from approximately 5 study […]

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Wave Life Sciences Ltd. SELECT-HD study endorsed* by EHDN

Study aims and goal: A Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of WVE-003 in adult patients with early-manifest HD who carry the targeted single nucleotide polymorphism (SNP)-SNP3. No. of study participants and sites: This phase Ia/II b study aims to recruit 36 participants from approximately 25 […]

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Preliminary results of the Proof-HD trial

Prilenia has announced preliminary results of its PROOF-HD trial on pridopidine on Huntington’s disease. While the study missed both its primary endpoint (an improvement in the Unified Huntington Disease Rating Scale-Total Functional Capacity) and a key secondary endpoint by (Composite Unified Huntington’s Disease Rating Scale (cUHDRS)), the company was encouraged by positive signals in a […]

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